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The Science

Breaking down our formula

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Our goal is to create the most effective whitening formula without ever sacrificing your oral health.

Our new formula combines 3 key ingredients to whiten and strengthen your teeth, with no sensitivity or lasting damage.

3 Active Ingredients,
1 Formulation

We’ve combined the effects of Potassium Nitrate, PAP, and Hydroxyapatite to whiten and brighten teeth, strengthen your enamel, and protect against sensitivity.

PAP

For safer whitening

Hydroxyapatite

For stronger teeth

Potassium Nitrate

For sensitivity prevention

The risks of traditional whitening methods

The risks of traditional whitening methods

Sensitivity

Sensitivity is a condition where tooth nerves are more susceptible to stimuli such as heat and cold. This is commonly caused by the dentin being exposed due to the loss of protective layers.1

Demineralisation is the loss of essential minerals from the tooth structure. This process can occur to the layers of enamel and dentin.12

Internal damage is related to cell damage to the tooth pulp,11 and the loss of important components from the tooths inner structure.6 Long-term effects can be severe and result in lasting damage.

Tissue damage is an injury caused by direct contact between harsh chemicals and the soft tissue within your mouth.10 This result is commonly referred to as a 'chemical burn'.

Replay

Sensitivity

Sensitivity is a condition where tooth nerves are more susceptible to factors such as heat and cold. This is commonly caused by the dentin being exposed due to the loss of protective layers.

Replay

Demineralisation

Demineralisation is the loss of essential minerals from the tooth structure. This process can occur to the layers of enamel and dentin.

Replay

Internal Damage

Internal damage is related to cell damage to the tooth pulp, and the loss of important components from the tooths inner structure. Long-term effects can be severe and result in lasting damage.

Replay

Tissue Damage

Tissue damage is an injury caused by direct contact between harsh chemicals and the soft tissue within your mouth. This result is commonly referred to as a 'chemical burn'.

What makes our formula safe?

Teeth whitening involves a process known as oxidation.2 This process occurs when a whitening agent comes into contact with the stains in your teeth. PAP and Peroxides both use oxidation to whiten, however, this process occurs in two very different ways.

Traditional Whitening

HiSmile’s PAP Formula


Enamel

During the process of oxidation, Hydrogen Peroxide releases molecules known as free radicals which come into contact with the enamel, during which a reaction occurs causing important minerals to be dissolved and washed away by saliva.3 When PAP causes oxidation, these same harmful radicals are not released. This means the enamel is left unaffected and can continue to protect the tooth from any external factors.5 We have also included Hydroxyapatite to replace any previously lost minerals from the tooth surface, improving the strength of the enamel.4


After damaging the tooth surface, the free radicals that Hydrogen Peroxide release are capable of making their way into the tooths internal structure where the dentin is located.6 When this happens, not only are important minerals lost, but the radicals also damage organic components such as collagen.7 As PAP exclusively oxidises stains without damaging the tooth, our formula is able to avoid any negative side effects.8 We have also included Hydroxyapatite and Potassium Nitrate to replace any previously lost minerals and protect the nerve from external stimuli.9


When the protective layers of enamel and dentin deteriorate from the use of peroxides,10 the nerve endings and tooth pulp are far more susceptible to damage. Some Peroxide formulas are capable of causing damage known as intensive oxidative stress, where irreversible cell tissue death (pulp necrosis) occurs.11 With PAP not causing adverse effects to the pulp tissue or furthering the loss of minerals, the internal tooth structure is left unharmed during the whitening process. In addition to not damaging the internal structure, our formula also contains hydroxyapatite which repairs damaged enamel and limits the exposure to any harmful external factors.


With over 46,000 employees in 1,000 locations worldwide, Intertek is one of the largest Total Quality Assurance providers in the world. For more than 130 years, industries have relied on Intertek to test and validate their products before hitting the market. They deliver a variety of in vitro methodologies for product evaluation, including enamel remineralisation, stain prevention / removal, and teeth whitening. In order to provide the highest quality products to our community, HiSmile has partnered with Intertek to conduct trials on our latest whitening and oral care formulas.

intertek

We worked with Intertek to conduct an in vitro study to understand the effects of different teeth whitening formulas

Change in Shades Whiter (Vita Bleachedguide Test)

7.86  shades

Improvement in VITA Bleachedguide

This study compared the effects of a 6% Hydrogen Peroxide formula, against the HiSmile PAP formula. Results were measured on a globally recognised scale known as the VITA Bleachedguide. After one ten-minute application, the HiSmile PAP formula achieved a result of 3.86 shades whiter, whereas the Hydrogen Peroxide formula only improved 1.97 shades. After the full course of six ten-minute treatments, the HiSmile PAP formula had shown maximum results of 7.86 shades whiter, with the Hydrogen Peroxide showing only 5.71 shades whiter.

Change in Surface Microhardness (Vickers Microhardness Test)

12.93  um

Improvement in tooth microhardness

Microhardness is one of the terms that refers to the strength of enamel. When microhardness reduces, it indicates that changes to the enamel have occurred. This exposes the internal tooth structure to further damage. The study identified that HiSmile's PAP formula gave a 12.93 units increase in microhardness, whereas a 6% Hydrogen Peroxide formula produced a significant decrease of 62.2 units.

We also invested in a dentist-led clinical trial to examine the impact and effects of our formula.

Dentist-Led
Clinical Trial
24 Subjects
Aged 19-55
10-Minute Whitening
Treatment
3.5 Shades Whiter
on Average

Real customers, real stories

  1. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3927677/
    DAVARI et al., Dentin Hypersensitivity: Etiology, Diagnosis and Treatment; A Literature Review, J Dent (Shiraz). 2013; 14(3): 136–145.
  2. https://onlinelibrary.wiley.com/doi/abs/10.1111/jerd.12519
    RODRIGUEZ-MARTINEZ et al., Tooth whitening: From the established treatments to novel approaches to prevent side effects, J Esthet Restor Dent. 2019; 31(5): 431-440.

    https://pubmed.ncbi.nlm.nih.gov/25969131/
    KWON et al., Review of the Mechanism of Tooth Whitening, J Esthet Restor Den. 2015; 27(5):240-57.
  3. https://www.sciencedirect.com/science/article/abs/pii/S0043164816305749?via%3Dihub
    RODRIGUES et al., Effect of bleaching teeth with hydrogen peroxide on the morphology, hydrophilicity, and mechanical and tribological properties of the enamel, Wear. 2017; 374-375:21-28.
  4. https://www.sciencedirect.com/science/article/pii/S0300571211000832
    TSCHOPPE et al., Enamel and dentine remineralization by nano-hydroxyapatite toothpastes, J Dent. 2011; 39(6):430-437.
  5. https://www.sciencedirect.com/science/article/pii/S2452213919300191?via%3Dihub
    QIN et al., A bio-safety tooth-whitening composite gels with novel phthalimide peroxy caproic acid, Compos Commun. 2019; 13:107-111.
  6. https://www.scielo.br/scielo.php?script=sci_arttext&pid=S0103-64402015000200135&lang=en
    BRISION et al., Demineralization and Hydrogen Peroxide Penetration in Teeth with Incipient Lesions, Braz Dent J. 2015; 26(2):135-140.
  7. https://pubmed.ncbi.nlm.nih.gov/30681930/#:~:text=Amide%20I%20was%20more%20affected,deleterious%20change%20in%20dentinal%20collagen.
    REDHA et al., Impact of Carbamide Peroxide Whitening Agent on Dentinal Collagen, J Dent Res. 2019; 98(4):443-449.
  8. https://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-77572017000500575&lng=en&tlng=en
    BIZHANG et at., Effectiveness of a new non-hydrogen peroxide bleaching agent after single use - a double-blind placebo-controlled short-term study, J Appl Oral Sci. 2017; 25(5): 575-584.
  9. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3908806/
    SHARMA et al., Evaluation of the clinical efficacy of potassium nitrate desensitizing mouthwash and a toothpaste in the treatment of dentinal hypersensitivity, J Clin Exp Dent. 2012; 4(1):e28-e33.
  10. https://www.nature.com/articles/4813423
    TREDWIN et al., Hydrogen peroxide tooth-whitening (bleaching) products: Review of adverse effects and safety issues, Br Dent J. 2006; 200:371-376.
  11. https://pubmed.ncbi.nlm.nih.gov/25527247/
    SOARES et al., Effect of hydrogen-peroxide-mediated oxidative stress on human dental pulp cells, J Den. 2015; 43(6):750-756.
  12. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5034904/
    ABOU NEEL et al., Demineralization–remineralization dynamics in teeth and bone, Int J Nanomedicine. 2016; 11:4743-4763.